Aspartame is a low-calorie sweetener. Aspartame is produced synthetically and the most commonly used sugar substitute worldwide. It can be found in over 5,000 different products such as soft drinks, yogurts, candy, chewing gum, etc. Aspartame is among the most thoroughly tested intense sweeteners and has an excellent safety profile. The safety of aspartame and other sweeteners has been evaluated by regulatory institutions all over the world. Authorities rely on the safety evaluations of independent scientific advisory bodies such as the European Food Safety Authority (EFSA), the United States Food and Drug Administration (US FDA), and the Joint FAO/WHO Expert Committee on Food Additives (JECFA).